CALCIUM DOBESILATE-A VENOTONIC DRUG

Venotonics are a class of medicinal which are used to alleviate venous diseases and disorders and are used to treat chronic venous insufficiency and edema.

These vasoprotective agents are a broad group of drugs that acts over the smooth muscle fibers from the venous wall, through calcium-dependant mechanisms modulated by an alpha-adrenergic neurohormonal regulation.

CALCIUM DOBESILATE (2,5 dihydroxy-benzene-sulfonate) is one such venotonic or vasoprotective agent that shows well defined pharmacological properties. 

Calcium Dobesilate works by acting on endothelium and capillary basement membrane thereby blocking hyperpermeability inhibiting platelet aggregation and inhibiting blood hyperviscosity and hence improving lymphatic drainage.

Calcium Dobesilate which was discovered more than 40 years ago is also used for the treatment of diabetic retinopathy and it is the only angio-protective agent that reduces the progression of this disease. It also shows antioxidant properties.

Synthesis of Calcium Dobesilate Monohydrate involves sulfonation of hydroquinone. Hydroquinone is present as CALCIUM DOBESILATE MONOHYDRATE - IMPURITY A.

Reference standards of Calcium Dobesilate Monohydrate API and Calcium DobesilateMonohydrate - Impurity A are available at Pharmaffiliates Analytics and Synthetics P. Ltd.

Pharmaffiliates is one of the leading integrated CRO which deals with the Custom synthesis of Reference standards, Impurities, Metabolites, Deuterated compounds and Phyto standards. We also offer our expertise in Analytical research, Stability studies, Formulation & Development, Quality assurance and Regulatory services.

Pharmaffiliates has a huge database of reference standards for over 10,000 products and all the reference materials are provided in pack sizes of 25mg and 50mg with over 98% purity. Customized pack sizes are also available as per customer’s requirement.

All the impurities supplied by Pharmaffiliates are with complete structure elucidation and data interpretation with high-end analytical techniques like NMR, MASS and Chromatographic purity along with detailed Certificate of Analysis.