Efavirenz- An Antiretroviral Drug

Antiretroviral or ARV is a medication used in the treatment of HIV/AIDS. It works by slowing down or preventing the growth of the virus, thereby slowing down the HIV disease.

The HIV/AIDS management includes multiple antiretroviral drugs, in order to control the HIV infection.

The use of multiple drugs helps in controlling different viral targets thereby maintaining the proper function of immune system. This leads to the prevention of opportunistic infections (infections caused by the pathogens in a weakened immune system) which may cause death.

Efavirenz (EFV) is one such antiretroviral drug which is sold by itself or taken in combination with as efavirenz/emtricitabine/tenofovir.

Efavirenz belongs to non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretroviral drugs and it works by inhibiting the activity of reverse-transcriptase (viral DNA polymerase) which is an essential requirement for HIV and other retrovirus replication.

Efavirenz is hence a crucial and significant pharmaceutical drug, synthesis of which involves highly stereo selective approach.

Pharmaffiliates Analytics and Synthetics P. Ltd. provide In-house Reference standards of Efavirenz API and impurities associated with it in the form of metabolites, degradants, intermediates and isomeric impurities etc.

All the Reference material available at Pharmaffiliates are provided with complete structure elucidation and data interpretation with high-end analytical techniques like NMR, MASS and Chromatographic purity along with detailed Certificate of Analysis.

The impurities that are identified and synthesized at Pharmaffiliates are:

Efavirenz amino alcohol methyl carbamate (Cas no- 211563-40-5), Efavirenz amino alcohol ethyl carbamate (Cas no- 211563-41-6) and Bis(ethoxycarbonyl) efavirenz amino alcohol    (Cas no- NA) which are the formed as a result of degradation of Efavirenz and present as impurities of Efavirenz.

Efavirenz Enantiomer (Cas no- NA) is the (R)-enantiomer of Efavirenz and it is present in biologically active (S)-enantiomer as an impurity.

(E)-Dihydro Efavirenz (Cas no- 440124-96-9) is again an isomeric impurity of Efavirenz.

Pack sizes of all the In-house Reference materials are provided in 25mg and 50mg vials. Customized pack sizes as per the customer’s need are also obtainable at Pharmaffiliates.

All the products are readily available in stock at Pharmaffiliates and these are delivered in a time and cost-effective manner.

Apart from the above mentioned In-house Reference materials, USP reference standard of Efavirenz is also available at Pharmaffiliates at a highly competitive price.