Canrenone- A bioactive metabolite of Spironolactone

Spironolactone, also known as a “water pill” is a drug used to remove excess fluid from the body build-up during congestive heart failure, cirrhosis of the liver, and kidney disease. Spironolactone is a prodrug with a short half-life and it is rapidly metabolized to its active form 7α-thiomethylspironolactone (7α-TMS). 7α-TMS is further converted to bioactive form Canrenone which is the major circulating metabolite.

Canrenone, which is a steroidal aldosterone antagonist is reportedly more potent as an antimineralocorticoid relative to its parent drug spironolactone. As an active metabolite Canrenone accounts for approximately 10 to 25% of the potassium-sparing effect (a diuretic which does not promote secretion of potassium in urine) of spironolactone and the other 80% is done by the other metabolite 7α-TMS.

Chemically, Canrenone is 10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione, most commonly used diuretic and an important intermediate for the synthesis aldosterone receptor antagonist Spironolactone

Pharmaffiliates Analytics and Synthetics Pvt. Ltd. proudly introduce the reference standard of Canrenone, details of which are mentioned below:

 

                                                           

Product name- Canrenone/Spironolactone impurity F    Product name- Canrenone D6 (major)

Product Code - PA 19 18060                                           Product Code - PA D 17260

CAS No.- 976-71-6                                                         CAS No.- NA

Pack size – 25mg, 50mg                                                  Pack size – 1mg, 10mg

The above-mentioned reference standards are supplied with a Certificate of Analysis, MSDS, and all the required documentation to ensure statutory domestic and international requirements. Our standards are of high purity and are scientifically characterized.

For more details visit our website www.pharmaffiliates.com

The laboratory and quality systems of Pharmaffiliates have successfully passed major second and third party audits which include NABL accreditation, ISO Guide 34 and USFDA.

Pharmaffiliates Analytics and Synthetics P. Ltd. is an integrated Contract Research Organization (CRO) is a gigantic name in the global market, which offers services to Pharmaceutical industry, API manufacturers, Bulk drug suppliers, clinical CROs and other allied industries.