Cetirizine-Second generation antihistamine drug

Histamine H1 receptor antagonists or antihistamines are the class of drugs used in the treatment of allergic disorders. They are classified as first generation sedating and second-generation non-sedating antihistamine. The non-sedation antihistamines do not easily cross the blood-brain barrier causing lesser or no drowsiness and thereby improving the lives of the patients.

Cetirizine, which was approved as a second-generation non-sedating antihistamine by FDA in September 1996 is one of the most commonly prescribed drugs for all ages by the medical practitioners.

Cetirizine, available as dihydrochloride salt works by blocking one type of receptor for histamine (the H1 receptor) and thus preventing the activation of H1 receptor-containing cells by histamine (a chemical that is responsible for many of the signs and symptoms of allergic reactions). 

Chemically, Cetirizine Dihydrochloride is [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride and it is a bioactive carboxylated metabolite of hydroxyzine.Cetirizine is a racemic compound and its organic synthesis involves several stereochemical steps which result in a number of impurities along with the desired products.

Identification, isolation, and characterization of these impurities is an indispensable process for Pharmaceutical companies, as these impurities may change the effectiveness and efficacy of the drug product.

Pharmaffiliates Analytics and Synthetics P. Ltd. have successfully performed impurity profiling of Cetirizine impurities and reference standards of these impurities are readily available in pack sizes of 25 and 50mg vials at Pharmaffiliates.

Detailed of Cetirizine impurities are listed below

Name of the impurity	Product code	CAS No.	Description
Cetirizine Dihydrochloride	PA 03 36000	83881-52-1	Second generation antihistamine
Cetirizine impurity A	PA 03 36010	303-26-4	Starting material used in the synthesis
Cetirizine impurity B	PA 03 36020	113740-61-7	A Decarbomethoxy impurity formed during synthesis
Cetirizine impurity C	PA 03 36030/ PA 03 36031 (Freebase form)	83881-59-8/NA	2-chloro impurity formed during synthesis
Cetirizine impurity D	PA 03 36040	346451-15-8	Dimer impurity of Cetirizine
Cetirizine impurity E	PA 03 36050/ PA 03 36051 (Freebase form)	83881-56-5/NA	Impurity formed during synthesis
Cetirizine impurity F	PA 03 36060/ PA 03 36061 (Freebase form)	83881-54-3/ 83881-53-2	Deschloro impurity
Cetirizine impurity G	PA 03 36070/ PA 03 36071 (Freebase form)	164726-80-1/ 109806-71-5	Important intermediate formed during synthesis
Cetirizine Lactose Ester (In-house impurity)	PA 03 36590	NA	A lactose adduct of Cetirizine

For more details and other impurities click on the link below

https://www.pharmaffiliates.com/impurities/1008/cetirizine%20dihydrochloride

All the above-mentioned impurity standards are available along with a Certificate of Analysis along with the detailed chromatograms and spectroscopic data.

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