Wednesday, 11 April 2018

Diltiazem - A non-dihydropyridine calcium channel blocker


Hypertension or high blood pressure is a signification cause of Cardiovascular diseases like Coronary artery diseases, atrial fibrillation or hypertensive heart disease which are the leading causes of deaths worldwide. Calcium channel blockers are the first line treatment for hypertension.

Diltiazem, a non-dihydropyridine calcium channel blocker, is an effective and safe antihypertensive drug, which can be used alone or in combination with other agents. Diltiazem works by inhibiting calcium channels in the vessels resulting in the vasodilation and, consequently,  lowering of the blood pressure.

The reference standard of Diltiazem Hydrochloride (Product Code- PA 04 26000, CAS No. - 33286-22-5) and the impurities associated with it are available at Pharmaffiliates.
Diltiazem impurity D or N-DESMETHYL DILTIAZEM HYDROCHLORIDE (Product Code- PA 04 26040, CAS No. - 130606-60-9) which is the major metabolite of Diltiazem is also available at Pharmaffiliates

For other impurities of Diltiazem and further details, follow the link below


Pharmaffiliates Analytics and Synthetics P. Ltd. is already an established name, as a leading manufacturer and suppliers of Reference materials worldwide.

All the standards are shipped with a Certificate of Analysis, MSDS, and all the required documentation to ensure statutory domestic and international reputations. Our standards are of high purity and scientifically characterized. Our laboratory and quality systems have successfully passed major second and third party audits which include NABL accreditation, ISO Guide 34 and USFDA.

Started in the year 2005, Pharmaffiliates is one of the leading integrated Contract Research Organization located in North India which offers its expertise in Custom synthesis (Reference standards, Impurities, Metabolites, Deuterated compounds, Phyto standards, agrochemicals, pesticides, food standards etc.), Analytical research (PH Buffer Solutions, Method development, Validation), Stability studies, Formulation & Development (New Drug Delivery System), Quality assurance and Regulatory Services.




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