Paracetamol-Over 100 years as an Analgesic and Antipyretic dDug

 Paracetamol or acetaminophen or APAP is undoubtedly one of the most commonly used drug worldwide, available over the counter, used in almost all ages, and forming Step 1 of the WHO analgesic ladder.

For over 100 years, Paracetamol is used as an effective analgesic and antipyretic agent. It is used to treat many conditions such as a headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

Paracetamol is synthesized in multistep where the starting material is phenol, which is nitrated to give a mixture of the ortho and para-nitrotoluene. The para-isomer is isolated and reduced to the para-amino group which is then acetylated to give Paracetamol.

During the multistep synthesis, several impurities arise, which may deteriorate the purity and efficacy of the final drug. Identification and isolation these impurities is a major challenge for Pharmaceutical companies.

Pharmaffiliates Analytics and Synthetics P. Ltd., a leading global CRO has been able to successfully identify, isolate, and characterize the impurities associated with Paracetamol. The reference standards of the below-mentioned impurities are available at Pharmaffiliates in the pack size of 25mg and 50mg.

Name of impurity	Product code	CAS No.	Application
Paracetamol impurity A	PA 16 06010	614-80-2	Impurity
Paracetamol impurity B	PA 16 06020	1693-37-4	Impurity
Paracetamol impurity C	PA 16 06030	3964-54-3	Impurity
Paracetamol impurity D	PA 16 06040	103-84-4	Impurity
Paracetamol impurity E	PA 16 06050	99-93-4	Used in the synthesis via Beckmann rearrangement
Paracetamol impurity F	PA 16 06060	100-02-7	An important intermediate in the synthesis of Paracetamol
Paracetamol impurity G	PA 16 06070	34523-34-7	Ketoxime intermediate formed during synthesis via Beckmann rearrangement
Paracetamol impurity H	PA 16 06080	2623-33-8	Impurity
Paracetamol impurity I	PA 16 06090	118-93-4	Impurity
Paracetamol impurity J	PA 16 06100	539-03-7	Impurity
Paracetamol impurity K	PA 16 06110/ PA 1606111(Hydrochloride salt)	123-30-8/ 51-78-5	Reactant used in the synthesis of Paracetamol
Paracetamol impurity M	PA 16 06130	1752-24-5	Impurity
Paracetamol impurity N	PA 16 06140	3070-86-8	Impurity formed from Paracetamol

Pharmaffiliates offers all the above-mentioned impurity standards of Paracetamol with a Certificate of Analysis along with the spectroscopic data and chromatograms.

With over 10,000 impurity standards readily available in stock, Pharmaffiliates leads the chart in the manufacturing of pharmaceutical impurity standards, Chemical Intermediates, Drug Metabolites, Drug analogs, Analytical Standards and reference standards in the country.

Pharmaffiliates is one of the leading Impurity manufacturers and impurity suppliers across the globe.