Calcipotriene- A vitamin D3 analog

Calcipotriene, also known as Calcipotriol is a synthetic derivative of Calcitrol which is an active metabolite of Vitamin D.

A vitamin D3 analog, Calcipotriene is a valuable drug used as a first- or second-line therapy option for the management of mild to moderate psoriasis. Calcipotriene works by inhibiting cell proliferation and enhancing cell differentiation in the skin of patients with psoriasis.

Synthesis of Calcipotriol involves various stereo selective processes and therefore, several undesired isomers and diastereomers were formed during its synthesis. In-House Reference standards of these are available at Pharmaffiliates Analytics and Synthetics P. Ltd

1.     Calcipotriene - impurity B or (7Z)-Calcipotriol

2.     Calcipotriene - impurity C or (5E)-Calcipotriol

3.     Calcipotriene - impurity D or 24-epi-Calcipotriol

Calcipotriene - Impurity B and Calcipotriene - impurity C are the geometric isomers of Calcipotriene present as an impurity and are formed during its synthesis.

Calcipotriene - Impurity D is a C-24 diastereomer of Calcipotriene formed as an undesired product during the synthesis of Calcipotriene.

All the above mentioned in-house standards are available at Pharmaffiliates in a pack size of 25mg and 50mg at a very competitive price. Pack size can also be customized as per the need of the customer.

All the impurities supplied by Pharmaffiliates are with complete structure elucidation and data interpretation with high end analytical techniques like NMR, MASS and Chromatographic purity along with detailed Certificate of Analysis.

Apart from the above mentioned products Pharmaffiliates also deals in EDQM standards of Calcipotriol. Calcipotriol (anhydrous) - reference spectrum, Calcipotriol monohydrate and Calcipotriol monohydrate - reference spectrum from EDQM are available with Pharmaffiliates at a very competitive price.